摘要
目的：研究ＣＤ４４ｖ６在大肠癌肝转移中的作用，探索一种有效的抗肿瘤转移方法。方法：应用大肠癌肝转移模型来研究ＣＤ４４ｖ６单抗对大肠癌ＨＴ２９、Ｌｏｖｏ细胞裸小鼠实验性肝转移的影响，分析ＣＤ４４ｖ６单抗在抗大肠癌肝转移中的作用。结果：ＨＴ２９细胞对照组肝转移率为４／８，实验组肝转移率为２／８；Ｌｏｖｏ细胞对照组肝转移率为８／８，实验组肝转移率为０。结论：ＣＤ４４ｖ６单抗能有效阻断裸小鼠实验性大肠癌肝转移的发生。
Objective: To investigate the action of CD44v6 on human colorectal cancer (HCC) liver metastasis and to search for an antimetastatic remedy. Methods: Experimental liver metastasis model of nude mice was used to study the role of CD44v6 antibody against metastasis. Results: 4/8 of the nude mice had liver metastasis after intrasplenic transplantation of HT29 cells and 8/8 of the nude mice had liver metastasis after intrasplenic transplantation of Lovo cells. When HCC cells were blocked by CD44v6 antibody, 2/8 of the nude mice that were transplanted with HT29 cells had liver metastasis, but none of the nude mice transplanted with Lovo cells had. Conclusion: The antibody specific for CD44v6 can block experimental liver metastasis of HCC in nude mice. With the finding of a CD44v6 ligand-like substance a new approach to prevent HCC metastasis is in sight.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第2期139-142,共4页
Chinese Journal of Clinical Oncology
基金
全军"九五"攻关项目
关键词
动物模型
CD44V6
大肠肿瘤
肝转移
Human colorectal cancerMetastasisAnimal modelCD44v6Anti-metastasis
