摘要
目的:观察调节性T细胞在慢性肝病中的变化及其临床意义。方法:用流式细胞仪检测患者的CD4+CD127loCD25hi-int调节性T细胞。比较不同慢性肝病患者(慢性乙型肝炎、乙肝肝硬化、肝癌)间CD4+CD127loCD25hi-int调节性T细胞的表达情况。结果:不同慢性肝病患者间调节性T细胞的表达有差异,但无统计学意义,肝癌患者最高,乙肝患者次之,肝硬化患者最低,但均高于健康对照。结论:调节性T细胞与慢性肝病显著相关。
Objective：To investigate the change and the role of regulatory thymus cell in patient with chronic liver disease.Methods：CD4＋CD127loCD25hi-int regulatory thymus cell （Treg） was tested by Flow Cytometry.The levels of Treg in patients with chronic liver disease （chronic hepatitis B,cirrhosis,liver cancer） were compared.Results：Treg level in patient with chronic liver disease group was significantly higher than healthy control group.But there wasn＇t significant differences among patients with chronic hepatitis B、cirrhosis and liver cancer.Conclusion：The levels of Treg is relation with chronic hepatic disease.
出处
《陕西医学杂志》
CAS
2010年第7期831-833,共3页
Shaanxi Medical Journal
基金
天津市重点科技攻关专项资助项目(05YFSJSF02500)
国家重点基础研究发展规划(973计划)资助项目(2007CB512801)
