摘要
目的对2型糖尿病患者有胰岛素抵抗(IR)一级亲属进行生活方式干预后,观察其胰岛β细胞功能及胰岛素敏感性的变化及IR改善情况。方法将T2DM家系非DM但具有明显IR的一级亲属46人分为生活方式干预组与非干预组,定期观察各项指标,随访2年。结果干预组经生活方式干预后BMI降低,2hPG、TG水平降低(P<0.05),高胰岛素水平改善(P<0.01),IR程度明显减轻(P<0.01)。结论干预可以改善胰岛素敏感性,减轻IR,对减少糖尿病的发生,减少大血管并发症的形成具有积极的意义。
Objective Observe the changes in islet cell function and insulin sensitivity after the life style intervention in the insulin resistance first-degree relatives of type 2 diabetics. Results The blood glucose at two hours after meal (2hPG), body mass index (BMI), triglycerides level were significantly reduced (P〈0. 05) after intervention and high insulin level was improved (P〈 0. 01 ). The degree of insulin resistance was obviously relieved (P〈0. 01). Conclusions The life style intervention can improve insulin sensitivity and relieve insulin resistance, which may contribute to decreasing development of diabetes.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2010年第3期173-175,共3页
Chinese Journal of Diabetes
基金
陕西省2003年科技攻关资助项目(2003K10-G100)
关键词
糖尿病
2型
一级亲属
胰岛素抵抗
生活方式
干预
Diabetes mellitus, type 2
First-degree relative
Insulin resistance
Life style
Intervention treatment