摘要
目的：寻找能兼顾防治高脂血症、动脉粥样硬化和脂肪肝的有效药物。方法：观察普伐他丁、维生素Ｅ、卡托普利对家兔高脂血症、动脉粥样硬化和脂肪肝形成的影响。结果：普伐他丁可显著降低血脂和改善动脉粥样硬化病变，并有抗脂肪肝作用，联用维生素Ｅ可减轻其潜在的肝毒性；卡托普利有一定的抗动脉粥样硬化作用，且不影响血脂和肝脂质代谢。结论：普伐他丁联用维生素Ｅ、卡托普利可安全用于高脂血症。
Objective:To search for effective drugs on prevention and treatment of hyperlipidemia,atherosclerosis and fatty liver.Methods:To observe the influence of Pravastatin, Vitamin E and Captopril on the development of hyperlipidemia,atherosclerosis and hepatic steatosis in rabbits induced by high fat diet.Results:Pravastatin was effective in prevention and treatment of hyperlipidemia and atherosclerosis in rabbits(n=6)induced by high lipid diet. Moreover,it was also effective in reducing steatosis,but may aggravate liver damage.Pravastatin plus Vitmain E(n=5) might alleviate the potential hepatotoxicity of the former.Captopril(n=6)not only had an anti-atherosclertic effect to a certain degree,but also had no influence on the blood lipid and lipid metabolism of liver.Conclusion:Pravastatin plus Vitamin E and captopril are safe and effective in the treatment of hyperlipidemia,atherosclerosis and fatty liver.
出处
《上海医学》
CAS
CSCD
北大核心
1998年第12期709-711,共3页
Shanghai Medical Journal
关键词
高脂血症
动脉粥样硬化
脂肪肝
普伐他丁
Hyperlipidemia Atherosclerosis Fatty liver Pravastatin Vitamin E Captopril
