摘要
目的：前瞻性观察短期静脉输注脂肪乳剂对病人肝胆汁脂质组成和胆汁成石性的影响，探讨脂肪乳剂在ＴＰＮ继发胆道疾患中的作用。方法：２５例胆总管结石病人被随机分成三组，术后１～３天，对照组每天仅予以常规补液处理，２０％Ｉｎｔｒａｌｉｐｉｄ（２０％ＩＬ）组和１０％ＩＬ组则分别予以静脉输注２０％ＩＬ５００ｍｌ／ｄ和１０％ＩＬ１０００ｍｌ／ｄ。研究前后分别取“Ｔ”管胆汁，测胆酸（ＢＡ）、磷脂（ＰＬ）和胆固醇（ＣＨ），计算胆固醇饱和指数（ＣＳＩ）。结果：与研究前比，三组肝胆汁ＢＡ均有显著升高；２０％ＩＬ组和１０％ＩＬ组肝胆汁ＰＬ浓度显著升高。与对照组比，２０％ＩＬ组和１０％ＩＬ组肝胆汁ＰＬ以及１０％ＩＬ组ＢＡ浓度均有显著升高。ＣＳＩ在三组虽较研究前均有下降，但组间均未见显著差异。结论：短期输注脂肪乳剂可引起肝胆汁中脂质成分的改变，但并不增加肝胆汁的成石性。
Objectives:This study was designed to investigate the effect of short term intraveous fat emulsion on human hepatic bile lipid composition and its lithogenicity. Methods:Twenty five patietns with common bile duct stone were randomly divided into three groups.After operation,the control group just received route treatment,and the groups of 20%IL and 10%IL were given 20%UL(500 ml/d) and 10%IL(1 000 ml/d) for 3 days respectively.Bile samples were obtained from T tube before and after the study to estimate BA,PL,CH composition,and CSI were then calculated. Results:Hepatic bile phospholipid was increased in 10%IL and 20%IL groups( P <0.05),bile acid in hepatic bile increased in 10%IL group( P <0.05).Hepatic bile cholesterol was increased in 10%IL and 20%IL groups,but these changes were not statistically significant.CSI showed no significant difference among three groups. Conclusions:Shot term intravenous fat emulsion may affect hepatic bile lipid composition,but didnt increase lithogenicity of hepatic bile in human.
出处
《肠外与肠内营养》
CAS
1998年第4期199-201,共3页
Parenteral & Enteral Nutrition
