摘要
以天然樟脑为原料，经过磺酰化、酰氯化、酰胺化、环化、还原５步反应合成了Ｄ（－）樟脑磺内酰胺（１）．本方法操作简便，反应时间短，总产率达４０９％．（１）是一种优良的手性助剂，广泛应用于不对称合成．
Imine was made from camphor throungh sulfonating, chlorinating, reacting with NH 3·H 2O, NaOCH 3catalyzed cyclizating of amide individually Then reducting of imine with LiAlH 4 gave a potential chiral auxiliary D (-)camphor sultam in 40 9% yields over the value in present references Comparing with other's work, this method took a shorter time, operated more simply and gave higher yields
出处
《湖北大学学报（自然科学版）》
CAS
1998年第3期253-255,共3页
Journal of Hubei University：Natural Science
