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特异AT序列结合蛋白1与肿瘤关系的研究进展 被引量：1

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摘要 特异AT序列结合蛋白1(special AT rich sequence binding protein,SATB1)是一种组织特异性的核基质结合蛋白,参与了染色质高级结构的形成和组织特异性基因的表达调控,并通过与核基质附着区(matrix attachment regions,MARs)序列结合以促进基因重组和染色质重建,从调节组蛋白乙酰化和甲基化水平等多种途径对基因的表达进行调控,在免疫调节、凋亡调控和肿瘤转移方面发挥重要的作用。本文将近年来有关SATB1与肿瘤关系的研究进展作一综述。
作者 向江东 席晓薇
机构地区 上海交通大学附属第一人民医院妇产科
出处 《肿瘤》 CAS CSCD 北大核心 2009年第11期1101-1103,共3页 Tumor
关键词 肿瘤 核基质附着区结合蛋白质类 染色质组装和分解 肿瘤转移
分类号 R730.23 [医药卫生—肿瘤]
  • 相关文献

参考文献25

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二级参考文献43

  • 1张德超,毛友生,黄国俊.中国肺癌外科治疗概况与进展[J].中国肺癌杂志,2005,8(6):557-562. 被引量：28
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共引文献33

同被引文献8

  • 1Galande S,Purbey KP,Notanil D, et al. The third dimension of gene regulation:organization of dynamic chromatin loop- scape by SATBI[J]. Curr Opin Genet Dev,2007,17(5):408.
  • 2Nakayama Y, Mian IS, Kohwi-Shigematsu T, et al. A nu- clear targeting determinant for SATB1, a genome organizer in the T cell lineage[ J]. Cell Cycle,2005,4(8 ) :1099.
  • 3Tu W, Luo M, Wang Z, et al. Up regulation of SATB1 promotes tumor growth and metastasis in liver cancer[ J]. Liver Int,2012,32 (7) : 1064.
  • 4Han H, Russo J, Kohwi Y, et al. SATB1 reprogrammes gene expression to promote breast tumour growth and me- tastasis [ J]. Nature ,2008,452 (7184) : 187.
  • 5Patani N, Jiang W, Mansel R, et al. The mRNA expression of SATB1 and SATB2 in human breast cancer[ J]. Cancer Cell Int,2009,9 :18.
  • 6EI-Serag HB, Rudilph KL. Hepatocellular carcinoma : epi- demiology and molecular carcinogenesis [ J ]. Gastroenter- ology ,2007,132 (7) :2557.
  • 7Kobierzycki C, Wojnar A, Dziegiel P. Expression of SATB1 protein in the duetal breast carcinoma tissue mi- croarrays-preliminary study [ J ]. Folia Histochem Cytobi- ol,2013,51 (4) :333.
  • 8彭正奎,杨定华,李湘竑,黄毓,张国强,钟克波,毕民平,李光辉.肝细胞肝癌组织SATB1表达及其临床意义的研究[J].中华肿瘤防治杂志,2011,18(9):697-700. 被引量：9

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肿瘤
2009年 第11期

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