Bmi-1,a Polycomb Group Protein,Plays an Essential Role in Tumorigenesis and Metastasis
Bmi-1,a Polycomb Group Protein,Plays an Essential Role in Tumorigenesis and Metastasis
摘要
Dysregulation of polycomb group protein Bmi-1 expression has been linked with an invasive phenotype of certain human cancers and poor prognosis of patients; however, the underlying mechanisms are
Dysregulation of polycomb group protein Bmi-1 expression has been linked with an invasive phenotype of certain human cancers and poor prognosis of patients; however, the underlying mechanisms are poorly understood. Here, we demonstrate that Bmi-1 expression is inversely correlated with E-cadherin expression in various cancers. We find that overexpression of Bmi-1 causes epithelial to mesenchymal transition （EMT）, enhances cell motility/invasiveness, and contributes to the promotion of tumorigenesis and metastasis; whereas silencing Bmi-1 expression in cancer cells reverses EMT and reduces metastatic potential. Overexpression of Bmi-1 stabilized the E-cadherin regulator,
出处
《中国肺癌杂志》
CAS
2009年第6期I0063-I0063,共1页
Chinese Journal of Lung Cancer
关键词
肺癌
医学
治疗
疗效
Polycomb group protein
Bmi-1
Metastasis
Epithelial-mesenchmal transition
Snail
E-Cadherin
