摘要
本文研究了氯霉素单次静脉注射后,在健康、沙门氏菌病和肝损害小型猪体内的药代动力学,以观察疾病对氯霉素在动物体内变化过程的影响.从颈静脉导管采血.药物浓度用高效液相色谱法测定.结果表明,沙门氏菌感染和肝损伤后。氯霉素的动力学发生显著改变.在健康动物体内为一室开放模型.消除半衰期(l_(1/2)β)为1.1h.而在两种疾病动物体内则为二室开放模型,消除半衰期(l(1/2)β)分别为1.68h和1.63h。极显著延长(p<0.01).最后根据有关动力学参数制定了相应的给药方案.
Using mini—pigs with an indwelling vascular catheter, the pharmacokinetics of CAP was investigated in healthy, salmonellosis and liver—damaged animals. It showed that the infection of salmonella and the damage of liver could change the kinetic course of CAP significantly. Chloramphenicol in healthy pigs performed as one-compartment open model with a half—life of1.1h. Kinetic course of CAP in salmonellosis and liver—damaged pigs was described using two—compartment open model, and the halflife (1.68h and 1.63h respectively) was increased significantly (p<0.01). Dosage schedules were calculated respectively based on this research.
出处
《江苏农学院学报》
CSCD
1990年第1期55-59,共5页
Jiangsu Agricultural Research
关键词
氯霉素
猪
肝损害
药代动力学
chloramphenicol
pharmacokinetics
salmonellosis
liver damage
mini-pig
HPLC
