摘要
提出一种基于电荷迁移反应简便可靠地测定头孢羟氨苄的分光光度法。在甲醇－乙醇介质中，头孢羟氨苄与氯冉酸于５０℃反应１５ｍｉｎ能够形成稳定的１：１络合物，其λｍａｘ＝５２８ｎｍ，线性范围为２０～４００ｍｇ／Ｌ。用拟定的方法测定原粉和胶囊，结果与药典法一致。对浓度１００ｍｇ／Ｌ的药物１０次测定相对标准偏差为１．４％，样品的标准加入回收率为９９．０％～１００．８％。
A simple and reliable spectrophotometric method for the determination of cefadroxil has been developed based on the charge-transfer reaction. Cefadroxil is reacted with chloranilic acid in a mixture of methanol and ethanol at 50℃ for 15 min and a rose complex is formed. Experiment shows that the maxium absorption of the complex is at 528 nm and the molar ratio of cefadroxil and chloranilic acid is l:1. The linear range of the determination is 20-400 mg/L. The proposed method has been applied to the analysis of cefadroxil pharmaceutical raw material powder and capsules with satisfactory results. The recoveries are 99.0% ~ 100.8%. The relative standard deviation is 1.4%(n=10).
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1998年第3期310-313,共4页
Chinese Journal of Analytical Chemistry
关键词
电荷迁移反应
头孢羟氨苄
氯冉酸
光度法
Charge-transfer reaction, cefadroxil, chloranilic acid, spectrophotometry
