摘要
目的：研制和应用脑弥漫轴索损伤（ＤＡＩ）致伤装置．方法：自行设计制作头颅旋转致伤装置，保证其可使动物头颅于瞬间旋转特定角度（１５°～９０°），仅以大鼠为对象进行力学、行为及病理效应评价．结果：①力学参数测定（以体重２１０ｇ大鼠转９０°为例），旋转角速度为８０１２７ｒａｄ／ｓ，角加速度２０４４×１０５ｒａｄ／ｓ２，用时约２ｍｓ；角速度及角加速度均大于Ｍａｒｇｕｌｉｅｓ提出的ＤＡＩ的外力阈值．②行为及病理观察表明旋转后大鼠符合ＤＡＩ特征．结论：本装置可用于制作大鼠ＤＡＩ模型。
Aim:Designing, producing and applying a device for diffuse axonal injury(DAI) of the brain in animalsMethods: A rotating device for the head of animals was made,which could move the animal′s head through a designated angle (15°- 90 ° ) instantly Mechanical parameters were caculated with the head of a 021 kg rat rotating by 90° Result:(1)The rotating time was approximately 2 ms and the angular volecity and angular acceleration were 80127 rad/s and 2044×105 rad/s2 which were far beyond the force threshold of DAI proposed by Margulies (2)Behavioral and pathological observations showed that the rotated rats possessed the typical characteristics of DAI Conclusion: Our injury device can produce rat DAI models,and can be used to the other animals as well
出处
《第四军医大学学报》
1998年第1期87-89,共3页
Journal of the Fourth Military Medical University
