摘要
给鼠饲以添加不同含量的高锌饲料，分别于每ｋｇ干饲料中加硫酸锌２００（Ｚ１组），４００（Ｚ２组），８００（Ｚ３组），１２００（Ｚ４组）ｍｇ／ｋｇ。历时１２周观察其海马的形态学变化。结果显示：①光镜下海马结构无明显改变。②电镜下Ｚ１组、Ｚ２组海马结构基本正常。Ｚ３、Ｚ４组神经元内线粒体内部嵴断裂，基质淡化，严重者呈空泡变性，溶酶体增多，髓鞘融合，突触数量明显减少。提示服用过高剂量锌可引起海马超微结构的改变，从而影响脑功能。
Pathological changes in hippocampus of rats fed with different zinc content food(Z1 200mg,Z2 400mg,Z3 800mg,Z4 1200mgZnSO 4/kg)were observed.The results were as follows:(1)there were no obvious pathological changes in hippocampus in Z1 and Z2 groups under light and electron microscopic examinations;(2)in Z3 and Z4 groups,no obvious pathological changes were observed under lihgt microscopic examination,however,under electron microscopic examination,the mitochondria were badly damaged:the eristae were blured,broken and even disapperaed,thus the mitochondria became vacuolized;the myelin sheaths became fused,and the density of synaptosomes decreased.The results indicated that high dose of zinc wuold have toxic effect on hippocampus in rats.
出处
《微量元素与健康研究》
CAS
1997年第3期7-9,共3页
Studies of Trace Elements and Health
关键词
高锌饮食
海马
超微结构
大鼠
high zinc diet
hippocampus
ultrastructure
rat
