摘要
目的探讨2型糖尿病(T2DM)急诊患者发生肝胆疾病的危险因素。方法对186例急诊的2型糖尿病患者临床资料进行二分类Logistic回归分析。结果本组中T2DM患者中肝胆疾病的发病率为45.7%。发生肝胆疾病与无肝胆疾病者之间除了性别比例和吸烟状况的差异无统计学意义(P=0.540和0.287)外,年龄、糖尿病病史、饮食控制、饮酒、BMI、FPG、TC、TG、HDL-C、LDL-C、GHbA1c、合并冠心病和脑血管病以及糖尿病治疗情况的差异均有统计学意义(P<0.05)。脂肪性肝病危险因素有BMI、LDL-C、GHbA1c和合并冠心病(P<0.05);保护性因素有糖尿病病程和合并脑血管病(P<0.05)。胆囊炎危险因素有TC、LDL-C和GHbA1(cP<0.05);保护性因素有年龄和HDL-C(P<0.05)。胆石病危险因素有TG和TC(P<0.05);保护性因素为年龄(P<0.05)。肝功能损害危险因素有重度饮酒、TC、GHbA1c和冠心病(P<0.05);保护性因素有年龄和HDL-C(P<0.05)。结论在T2DM患者治疗过程中,稳定血糖、调节脂质代谢紊乱、控制体重、中青年患者加强健康教育,提高他们的治疗依从性,对防治T2MD肝胆疾病具有重要的意义。
Objective To investigate the risk factors of hepatobiliary diseases in emergency patients with type 2 diabetes mellitus （T2DM）. Methods The clinical data of 186 emergency cases with T2DM, 40 males and 45 females, aged （48.9±7.8）, were analyzed by binary logistic regression. Results Incidence of liver ＆ gall diseases in this study were 45.7%. In patients with T2DM, except for gender ratio and smoking condition, their age, diabetes mellitus history, alimentary control, drink alcohol, BMI, FPG, TC, TG, HDL-C, LDL-C, GHbA1c, complicating coronary heart and cerebrovascular diseases had statistic difference （P 〈 0.05）between groups with and non liver ＆ gall diseases. Risk factors of hepar adiposum included BM I, LDL-C, GHbA1c and complicating coronary heart diseases （P 〈 0.05）; and protective factors included course of T2DM and complicating cerebrovascular diseases （P 〈 0.05）. Risk factors of cholecystitis included TC, LDL-C and GHbA1c （P 〈 0.05）; and protective factors included age and HDL-C （P 〈 0.05）. Risk factors of gallstone included TG and TC （P 〈 0.05）; and protective factors was age （P 〈 0.05）. Risk factors of liver disfunction included heavy drinking, TC, GHbA1c and complicating cerebrovascular diseases （P 〈 0.05）; and protective factors included age and HDL-C （P 〈 0.05）. Conclusion During managing patients with T2DM, stabilizing blood glucose, regulating lipid metabolic disorder; reducing weight, emphasizing young and middle--aged patients＇ healthy education and raising their compliance to management were very important for preventing and curing liver ＆ gall diseases.
出处
《中国急救复苏与灾害医学杂志》
2008年第2期85-88,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
2型糖尿病
肝胆疾病
危险因素
Type 2 diabetes mellitus （T2DM）
Liver ＆ gall diseases
Risk factors
