摘要
用特异性放免法测定45例原发性高血压（EH）患者血浆肾上腺紧张素［ADM（153－185）］的水平。结果示EH组低于肾实质性高血压组，亦明显低于对照组；EHⅠ、Ⅱ、Ⅲ期的血浆ADM（153－185）水平组间比较有显著或非常显著差异（P＜0．05～0．001）；经降压治疗4周的30例EH患者血浆ADM（153－185）水平明显上升。提示ADM在调节血管舒缩中可能起一定作用。
Plasma adrenotensin [Adrenomedullin, ADM (153-185)] level was measured by specific radioim-munoassay in 45 patinents with essential hypertension (EH). The results showed that plasma ADM(l53-185) lev-el of EH group was lower than that of renal parenchymal hypertension group (P<0.01) and control group (P<o.001), The level of plasma ADM(153-185)had significant difference among I, and stage of EH while com-pared with each other (P<0. 05~0.0001). ADM (153-185) level was markedly increased (P<0.001) after 4 weeks' follow up in 3o patients who received antihypertensive treatment- These data suggested that changes of plasma ADM(153-185) may play an important role in the regulation of vasomotortonicity.
出处
《江苏医药》
CAS
CSCD
1997年第4期233-235,共3页
Jiangsu Medical Journal
关键词
肾上腺紧张素
原发性
高血压
Adrenotensin Essential Hypertension Clinical Significance
