摘要
同烧伤一样，机械性创伤时机体血清同样存在低分子量的免疫抑制物，我们发现并证实分子量约９０００的创伤血清抑制物对ＩＬ一２及ＩＬ－２Ｒ蛋白表达具有强烈的免疫抑制作用，且对ＩＬ－２和ＩＬ－２ＲｍＲＮＡ的转录也具有明显的抑制作用。从而揭示：这种创伤血清免疫抑制物对淋巴细胞的抑制作用发生于ｍＲＮＡ转录前水平，可能与细胞起始活化信号的识别和受阻有关。
An immunosuppressive abaormal protein with molecular weight of about 9000 dalton was found in our previous work The immunosuppressive action of the abnormal protein on interleukin-2 (IL-2), and lL - 2 receptor were further examined. The results indicated that the expressions of proteins of IL - 2 and IL - 2 receptor were depressed, the transcriptions of the mRNA of IL - 2 and IL - 2 receptor were also suppressed by the immunosupprosive substance.It was suggested that the suppression took place before the transcription of mRNA, and the abnormal pro- tein might suppress the lympbocytic function through the action of recognition of initial signal of cell activation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1997年第1期1-3,共3页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
关键词
创伤
免疫抑制剂
白细胞介素
MeSH Wounds and injuries ·Immunosuppressive agents ·Interleukin - 2
