摘要
目的:观察血塞通注射液与贝那普利(洛丁新)联合治疗糖尿病肾病(DN)的临床疗效。方法:将80例(DN)患者随机分为治疗组(42例)和对照组(38例),两组均予常规降糖治疗,贝那普利口服每次10mg,每日1次。治疗组予血塞通注射液210mg加入生理盐水250mL静脉注射,每日1次,15d为1个疗程,停用5d后开始第2疗程,共2个疗程。结果:两组SBP、DBP、FBG、PBG、24h尿蛋白定量、SCr、BUN、ALB、血液流变学、CHOL、TG治疗后与治疗前比较差异有统计学意义(P<0.05);治疗组治疗后24h尿蛋白定量、SCr、BUN、ALB、血液流变学与对照组治疗后比较差异有统计学意义(P<0.05)。结论:血塞通注射液与贝那普利联合应用治疗DN,在减少尿蛋白、改善肾功能方面明显优于单用贝那普利组,提示两药合用在延缓DN进展方面能够发挥各自优势,起到协同作用。
OBJECTIVE： To observe the clinical efficacy of xuesetong injection plus beinaxpril in treating patients with diabetic nephoropathy （DN）. METHODS： A total of 80 patients with DN were randomly assigned to trial group （n = 42） or control group （n = 38）. The control group was treated with common hypoglycemic agents plus 10 mg benazepril per os q.d. ; the trial group received not only the same drugs as in the control group, but also received 210mg xuesetong injection combined with 0.9% NS 250mL i.v.q.d, for 2 courses （1 course = 15days） with an interval of 5 days in between. RESULTS： SBP, DBP, FBG, PBG, 24h urine protein, SCr, BUN, ALB, hemorrheology, CHOL, TG in both group showed significant differences between pretherapy and post - therapy （ P 〈 0.05）. After treatment, significant differences were noted in 24h urine protein, SCr, BUN, ALB and hemorrhcolongy between the trial group and the control group （P 〈 0.05）. CONCLUSION： Combination of xuesetong injection and beinazepril showed a better efficacy than benazepil alone in reducing urine protein and improving of renal function in patients with DN, which indicates the synergistic effect of the two drugs in putting off the progression of DN.
出处
《中国医院用药评价与分析》
2007年第2期149-151,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
