摘要
[目的]了解葡萄球菌在临床上的分布及对常用抗菌药物的耐药性,为临床选择抗菌药物提供依据。[方法]用VITEK32型全自动细菌分析系统对我院临床分离的286株葡萄球菌进行鉴定,药敏试验采用K—B法,判断标准按NCCLS2002年版进行。[结果]共分离出葡萄球菌286株,其中金黄色葡萄球菌66株,耐甲氧西林金黄色葡萄球菌(MRSA)21株,占31.8%,凝固酶阴性葡萄球菌220株,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)186株,占84.5%;MRSA和MRCNS除对万古霉素和替考拉宁的耐药率为0%外,对其他大多数抗菌药物的耐药率均较高,甲氧西林敏感葡萄球菌(MSS)除对青霉素、氨苄西林、克拉霉素和红霉素等的耐药率(51.1%～88.9%)较高外,对其他抗菌药物的耐药率较低。[结论]该院葡萄球菌的耐药率有逐渐增高趋势,临床医师应根据药敏结果选择抗菌药物。
[ Objective] To understand the distribution of staphylococcus and it＇s drug resistance in antimicrobial drugs, to provide clinical referance for drug selection. [Methods] 286 strains staphylococcus were identified by 32 type VITEK in our affiliated hospital, susceptibility test was performed by （K-B） method, with the distinguishing standard according to NCCLS 2002. [ Results] 286 strains staphylococcus were separated. Among them, there were 66 strains staphylococcus aureus, 21 strains of which were medcillin-resistant staphylococcus （MRSA） and accounted for 31.8%, Coagulase-negative were 220 strains staphylococeus, 186 strains of which were meticillin-resistant coagurase-negative staphylococcus and accounted for 84.5% ; MRSA and MRCNS in drug tolerance rate were high to most of antimicrobisal agents except Vancomycin and Teicoplanin. The resistance rate of MSS to Penicillin, Ampicillin, Clarithromycin and Erythromycin were high （51.1%-88.9%）, while that to the rest antimicrobial agents were low. [Conclusions ] The drug tolerance rate of staphylococous increases gradually, physicians should select antibiotic drugs according to drug sensitivity.
出处
《现代预防医学》
CAS
北大核心
2007年第6期1154-1155,1159,共3页
Modern Preventive Medicine
关键词
葡萄球菌
耐药性
抗菌药物
Staphylococcus
Drug resistance
Antimicrobial agents
