摘要
目的研究液体与冻干狂犬病疫苗的临床反应和免疫原性。方法对300例暴露于狂犬病的病人进行常规5针注射,其中100例使用国产Vero细胞液体狂犬病疫苗,100例用国产Vero细胞冻干狂犬病疫苗,100例用进口Vero细胞冻干狂犬病疫苗,观察每针注射后的局部反应和全身反应;在免疫后14d和42d(全程注射后14d)用间接免疫荧光法检测抗体水平。结果国产液体疫苗、国产冻干疫苗和进口冻干疫苗局部反应发生率分别是28.6%、3.6%、3.2%。全身反应发生率分别是4.4%、1.2%、0.8%。免疫14d后国产液体疫苗、国产冻干疫苗、进口冻干疫苗的抗体阳转率分别是82%、96%,98%。免疫42d后抗体阳转率分别93.68%、98.98%、98.99%。结论冻干狂犬病疫苗的临床反应和免疫原性优于液体狂犬病疫苗。
Objective To investigate the side effect and immunogenicity of aqueous and lyophilized rabies vaccine. Methods For 300 cases of exposed rabies patients, 5 injections were administered, Vero cells aqueous rabies vaccine for 100 cases,Veto cells homemade lyophilized rabies vaccine for 100 cases and Veto cells import lyophilized rabies vaccine for the other 100 cases respectively. Local and systemic side effect after injection were observed, and the antibody level was detected with indirect immunofluorescence at 14 and 42 days after immunization （completion of injections）. Results The rate of local side effect of aqueous rabies vaccine, homemade lyophilized rabies vaccine, and import lyophilized rabies vaccine was 28.6 %, 3.6 %, and 3.2 % respectively, and the rate of systemic side effect was 4.4%, 1.2%, and 0.8% respectively. For homemade aqueous vaccine, homemade lyophilized vaccine and import lyophilized rabies vaccine, the antibody positive rate was 82.0 %, 96 %, and 98 % respectively after 14 days of immunization, and 93.68 %, 98.98 %, and 98.98 % respectively after 42 days of after immunization. Conclusion Lyophilized rabies vaccine surpasses homemade aqueous rabies vaccine in respect of side effect and immunogenicity.
出处
《中国计划免疫》
2007年第1期72-74,共3页
Chinese Journal of Vaccines and Immunization
关键词
液体与冻干狂犬病疫苗
临床反应
免疫原性
Rabies
Aqueous and lyophilized rabies vaccine
Side effect
Immunogenicity
