摘要
目的研究润红胭口服液改善营养性贫血的作用。方法选用SD大鼠,除空白对照组外,其余5组给予低铁饲料及去离子水造模20d后,分别给予润红胭口服液低、中、高剂量组0.84、1.67、5.00mL.kg-1药物,另给予阳性对照组2.0mg.kg-1硫酸亚铁;同时继续给予低铁饲料及去离子水,连续30d,测定血红蛋白(Hb)、红细胞数(RBC)、红细胞压积(HCT)、红细胞内游离原卟啉(FEP)和总铁结合力。结果润红胭口服3个剂量组大鼠Hb、RBC均高于模型组(P<0.01),中、高剂量组HCT均高于模型组(P<0.01);实验后各剂量组的FEP含量及血清总铁结合力均低于模型组(P<0.05)。结论润红胭口服液具有改善营养性贫血的作用。
OBJECTIVE： To investigate the effect of Runhongyan oral liquid on improving nutritional anemia. METHODS： The SD rats were divided into 6 groups. Except the blank control group, the other groups were fed with the iron - deficient forage and deionized water for 20 d to establish the design model. Among them, 3 groups： low dosage group, medium dosage group and high dosage group were treated with 0.84,1.67,5.00mL ~ kg t reagent, respectively. The positive control group was treated with 2.0mg·kg^-1 ferrous sulfate and then fed with the iron-deficient diet and deionized water for 30d. The blood index- Hb, RBC, HTC, FEB, total iron binding capacity was determined. RESULTS： The level of Hb and RBC of all dosage groups were higher than that in model control group（P〈0.01） .The level of HTC in medium dosage group and high dosage group were higher than that in model control group（P〈0.01） .The FEP and total iron binding capacity of all dose groups were lower than that in model control group（P〈 0.05）.CONCLUSION; Runhongyan oral liquid is effective in improving nutrition anemia. This study can provide reference for rational drug use in clinic.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第3期184-185,共2页
China Pharmacy
