摘要
目的探讨机械通气在胸部开放伤后海水灌入胸腔致急性肺损伤(ALI)救治中的应用。方法锐器致胸部开放伤后胸腔内灌注海水(35mL／kg)制备ALI成年杂交犬动物模型,随机分为未救治组、普通救治组、机械通气组,每组6只。未救治组在ALI出现后不实施任何救治措施,普通救治组给以鼻导管吸氧、胸腔闭式引流、静脉输入5％葡萄糖液等,机械通气组将普通救治组鼻导管吸氧改为机械通气。动态观察血气分析、血流动力学变化,检测外周血中炎症介质的变化。结果胸部开放伤后海水灌入胸腔可导致ALI,普通救治组PaO2虽有所升高但仍显著低于正常,机械通气能快速纠正低氧血症,两组在纠正高渗、高钠、高氯血症和改善血流动力学方面无显著差异。结论胸部开放伤后海水灌入胸腔引起严重ALI,机械通气具有良好的治疗效果。
Objective To observe the effects of mechanical ventilation on acute lung injury induced by seawater infusion following open chest trauma. Methods The model dog of acute lung injury induced by seawater infusion following open chest trauma was established,and 18 model dogs were randomly divided into three groups ： non-treatment group, common treatment group and mechanical ventilation group. The parameters of blood gas and hemodynamics were recorded. Blood samples were collected to assess changes of inflammatory cytokines （TNF-α,IL-4, IL-8）. Results Thoracic seawater infusion following open chest trauma could cause acute lung injury. PaO2 in the common treatment group was significantly lower than normal. Mechanical ventilation could improve oxygen partial pressure and the oxygenation index efficiently. The parameters of hemodynamic,plasma osmotic pressure and serum electrolytes were corrected in both common treatment group and mechanical ventilation group. Conclusions Mechanical ventilation is an effective method to treat acute lung injury induced by seawater infusion following open chest trauma.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2006年第4期193-195,共3页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
基金
海军科研计划课题基金资助项目(04-3304)
关键词
海水
急性肺损伤
机械通气
Seawater
Acute lung injury
Mechanical ventilation
