摘要
目的探讨尼莫地平对兔蛛网膜下腔出血(SAH)后症状性脑血管痉挛的影响。方法建立症状性脑血管痉挛动物模型,SAH+尼莫地平组静脉内应用尼莫地平,观察对比神经功能缺损症状改善、血液流变学及电镜结果。结果SAH+尼莫地平组随着尼莫地平的应用,神经功能缺损症状逐渐好转、血液流变学得到改善、透射电镜见基底动脉病理改变较SAH组减轻。结论SAH后早期应用尼莫地平对症状性脑血管痉挛具有明显的改善作用。
Objective To study the effects of nimodipine on symptomatic cerebral vasospasm after subarachnoid hemorrhage（SAil） in rabbits. Methods The experimental symptomatic cerebral vasospasm was induced. Nimodipine was given intravenously in SAH ＋ Nimodipine group. The neurological deficits, hemorrheologic changes and transmission electron microscopic examinations were observed and compared. Results By applying nimodipine, the neurological deficits were gradually improved and the hemorrheologic changes showed significant improvements. Meanwhile it was tested by transmission electron microscopic that pathological changes of SAH group were severer than that of SAH ＋ Nimodipine group. Conclusions Nimodipine given early after SAH may show effects on symptomatic cerebral vasospasm in rabbits remarkably.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2006年第9期1235-1237,共3页
Chinese Journal of Gerontology
关键词
蛛网膜下腔出血
症状性脑血管痉挛
尼莫地平
兔
Subarachnoid hemorrhage（SAH）
Symptomatic cerebral vasospasm
Nimodipine
Rabbits
