摘要
目的探讨青少年非酒精性脂肪肝(NAFLD)与脂肪炎性因子水平的相关关系。方法将126名受试者分为NAFLD组(n=82)和对照组(n=53),分别测定超敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、瘦素(leptin)、抵抗素(resistin)、血脂、血糖(FPG)、胰岛素(FINS)。结果NAFLD组hsCRP、TNF-α、瘦素、抵抗素、空腹胰岛素(FINS),甘油三脂(TG)水平显著性高于对照组(P<0.05～0.001),胰岛素敏感指数(ISI)显著性低于对照组(P<0.005);定义发生脂肪肝为1,不发生为0,回归分析显示进入回归方程的有hsCRP、TNF-α、抵抗素、ISI(P<0.05)。结论青少年NAFLDhsCRP、TNF-α、瘦素、抵抗素等炎性因子水平升高,且TG增高;炎性因子在NAFLD的发病中可能具有重要作用。
[Objective] To ascertain the relationship between the juvenile with nonalcoholic fatty liver disease （NAFLD） and the level of fatty inflammatory factors. [Method] 126 cases were recruited, and divided into NAFLD group （n=82） and controlling group （n=53）. Then hypersensitivity C- reaction protein （hsCRP）, tumor necrosis factor- α（TNF-α）, leptin, resistin, blood lipid, fasting plasma glucose （FPG）, fasting insulin （FINS） were determined. [Result] The concentration of hsCRP, TNF-α, leptin, resistin, FINS, triglyceride in NAFLD group was significantly higher than that in control group （P 〈0.05-0.001）, while the insulin sensitivity index （ISI） in NAFLD group was significantly lower than that in control group （P 〈0.005）. If NAFLD happens was defined it as 1; without was defined as 0. We put it with hsCR, TNF-α, leptin,resistin, blood lipid, FINS, FPG, ISI into regression analysis, and the regression equation includes hsCR, TNF-α, ISI （P 〈0.05）. [Conclusion] The lever of fatty inflammatory factors in juvenile with NAFLD such as hsCR, TNF-α, leptin, resistin, and so on rise, together with the increase of triglyceride. The fatty inflammatory factors may play a very important role on NAFLD.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第17期2632-2634,共3页
China Journal of Modern Medicine
关键词
非酒精性脂肪肝
C-反应蛋白
肿瘤坏死因子
瘦素
抵抗素
nonalcoholic fattv liver disease
C- reaction protein
tumor necrosis factor-α
leptin
resistin
