摘要
目的探讨风心病持续性房颤患者右房心肌细胞闰盘及肌原纤维的病理变化。方法选择29例风湿性二尖瓣置换术患者,根据有无持续性心房颤动分为心房颤动组(AF组)和窦律组(SR组),两组之间临床因素没有统计学差异。换瓣术中取右心耳心肌标本,电镜观察闰盘和肌原纤维。结果(1)AF组患者右房心肌闰盘缝隙裂开,缝隙中出现髓样、絮状物质,SR组患者则没有发现这种现象;(2)AF组肌原纤维的体密度为36.1±10.66%,SR组为43.72±8.9%(P<0.05),显示AF组有明显的肌原纤维溶解。结论风心病慢性AF与窦性心律患者右房肌细胞闰盘结构存在差异,AF组伴有明显的肌溶解,这些改变可能是导致风心病患者右房AF的重要病理基础。
Objective To study the pathological change of intercalated disk and myofibril of fight atrium in rheumatic heart disease （RHD） patients with AF. Methods Twenty-nine patients with mitral valve replacement of RHD were divided into AF group（n=13） and sinus rhythm（SR） group（n=16） according to chronic AF or not. There weren＇t significant statistical difference in clinical factors between two groups. During the operation of valve replacement, the samples of fight atrial appendages were taken and the qualitative and quantitative study were made by electron microscopy. Results （1）Split of intercalated disc（ID） gap was found in AF group, and there were marrowing and floccular substance in 1D gap. （2）Volume density of myofibril in AF group and SR group were 36.1±10.66% vs 43.72±8.9%（P〈0.05）, respectively. There was myofibril solution in AF group. Conclusion There are significant difference in intercalated disc and myofibril of right atrial myocardium between AF and SR with RHD. It is indicated that these changes should be the important pathological basis of RA fibrillation of AF patients with RHD.
出处
《江西医药》
CAS
2006年第7期437-439,共3页
Jiangxi Medical Journal
关键词
心房颤动
风湿性心脏病
病理学
肌原纤维
闰盘
atrial fibrillation
rheumatic heart disease
pathology
myofibril
intercalated disc
