摘要
目的:探讨广义估计方程在交叉试验等级资料中的应用,为临床试验交叉设计资料的正确分析提供方法学参考。方法:采用SAS软件包的GENMOD过程拟合模型,并以某治疗精神分裂症药物临床试验资料进行实例分析。结果:获得了各参数及其标准误的估计值,并可以对各因素进行直观的解释。结论:广义估计方程可以根据需要纳入如中心、年龄、性别、基线值等协变量进行分析,同时对缺失数据处理具有较好的稳健性,是处理交叉设计中等级资料的有效分析方法。
Objective： To explore the application of generalized estimating equation in ordered categorical data of cross - over trial analysis and provide methodology reference. Methods： An example was illustrated by modeling generalized estimating equation using the GENMOD command of SAS. Results： All parameters and their standard error were estimated, so every factor could be inmitionistic interpreted. Conehtsion： When using GEE, the accuracy of the estimation was improved, as well as covariates, such as the center, age, gender and baseline value could be taken into consideration. The method could also deal with data with missing values, it is useful in analysis of ordered categorical data of cross-over trial.
出处
《现代预防医学》
CAS
北大核心
2006年第7期1129-1130,共2页
Modern Preventive Medicine
关键词
广义估计方程
交叉设计
等级资料
Generalized estimating equation
Cross-over trial
Ordered categorical data
