摘要
本文应用一种较新的细胞毒试验方法——乳酸脱氢酶(LDH)释放法,检测了20例经尿道膀胱肿瘤电切术前的膀胱肿瘤病人和20名健康人的NK细胞活性,以及对10例病人术后膀胱内灌注BCG前后的NK细胞活性进行观测。发现灌注后1月患者NK细胞活性增高,半年后增高显著。对病人随访半年以上,临床基本上无肿瘤复发。故临床观察与NK细胞功能增强是一致的。并探讨了BCG灌注增强患者NK细胞活性的机理和NK细胞在肿瘤免疫监视上的意义。
NK cells could be the natural agents of tumour immunosurveillance. BCG immunotherapy mightinduce cellular immunity which might enhance NK cell activity. Prior to transurethral resection, 20 superficial bladder cancer patients as well as 20 healthypersons were tested of their NK cell activities. After TURB, 10 patients received intravesical instillation BCG for 1-2 courses. To test their NK cell activities periodically, we measured them with anewer microcytotoxicity method-an enzyme (LDH) release assay. The patients were then followedup over 6 months. There was no evidence of tumour recurence in our patients, and the NK cellactivities (% specific lysis) were highly significant (p<0.01).
出处
《北京医科大学学报》
CSCD
1990年第2期113-115,共3页
Journal of Peking University(Health Sciences)
关键词
膀胱肿瘤
卡介苗
NK细胞活性
NK cell activity
Superficial bladder cancer
Intravesical BCG
