摘要
目的研究不同的指纹图谱分析方法对中药质量评价结果的影响。方法以某中成药不同批次的色谱指纹图谱为基础,考核峰面积比值法、峰面积定量法和相似系数法对中药制剂质量评价结果的影响。结果峰面积比值法评价的正确率最高且最严格,相似系数法次之,峰面积定量法评价正确率最低也最为宽松且与现行评价方法的结果较为符合。结论不同的色谱指纹图谱评价方法会导致对中药质量评价结果的较大差异。
Objective To investigate the effects of different chromatogram fingerprints analysis methods on the quality evaluation of Chinese herbal medicine. Methods With the chromatogram fingerprints of a Chinese patent medicine in different batches as the analytic object, the quality evaluation of three methods such as peak area ratio, peak area quantification and similarity coefficient were investigated. Results The method of peak area ratio has the highest accuracy rate and the precise rate for quality evaluation, and similarity coefficient and peak area quantification came next. The result of peak area quantification was similar to that by current evaluation method. Conclusion Different chromatogram fingerprints analysis methods would result in a great difference in the quality evaluation of Chinese herbal medicine.
出处
《中药新药与临床药理》
CAS
CSCD
2006年第2期116-119,134,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家"十五"科技攻关项目(2004BA721A45)
关键词
中药色谱指纹图谱
峰面积比值
峰面积定量
相似系数
HPLC
中药质量评价
Chromatogram fingerprint of Chinese herbal medicine
Peak area ratio
Peak area quantification
Similarity coefficient
HPLC
Quality evatuation of TCM
