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脑出血大鼠脑水肿区脑组织明胶酶A、B基因表达的研究

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摘要 目的了解大鼠脑出血后脑组织明胶酶A,B基因表达情况,探讨其与脑出血后脑水肿的关系。方法70只大鼠,分为对照组、假手术组、模型组。假手术组与模型组于术后不同时间点取病灶周围水肿脑组织,对照组取相应部位脑组织,共扩增逆转录定量PCR法测定MMP-2、MMP-9基因表达水平。结果脑出血病灶周围水肿组织MMP-2、MMP-9基因表达水平明显高于对照组,其中MMP-2于术后48h达到高峰,MMP-9于术后12h表达达高峰,之后逐渐下降,但也高于对照组水平。结论明胶酶A,B在脑出血后周围组织水肿的形成中可能起着重要促进作用。
作者 陈大庆
机构地区 浙江温州医学院附属第二医院神经外科
出处 《重庆医学》 CAS CSCD 2005年第11期1685-1686,共2页 Chongqing medicine
关键词 明胶酶A 明胶酶B 脑出血
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献10

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共引文献7

重庆医学
2005年 第11期

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