摘要
用地塞米松（Ｄｅｘ）和肝素（Ｈｅｐ）Ｉｃ６０及Ｉｃ５０低一个剂量，对ＨＬ－６０细胞增殖、生长曲线和分裂指数均有明显的抑制作用，联合应用时抑制作用显著增强；对ＤＮＡ和蛋白质合成抑制作用大于ＲＮＡ，联合应用抑制作用均显著增强，提示两药抑制ＨＬ－６０细胞增殖、分裂和生长可能与它们抑制ＤＮＡ和蛋白质合成有关，亦与抑制ＲＮＡ合成有一定关系。
The proliferation,growth curve and mitotic index of human promyelocytic leukemia cell(HL-60)in vitro were markedly inhibited by Ic50 doses and lower doses of Dex and Hep.The effects of the combined Dex and Hep were stronger than the effects of Dex or Hep alone.Inhibitory effects of Dex and Hep on syntheses of DNA and protein were stronger than on the synthesis of RNA,the effects of combination was markedly stronger than the effects of Dex or Hep alone on DNA,RNA and protein synthesis.Inhibitory effects of Dex and Hep on proliferation, mitosis and growth of HL-60 cell were paralled with the inhibitory effects on the syntheses of DNA and protein.These results suggest that inhibitory effects of Dex and Hep on HL-60 cell may be related to inhibition of syntheses of DNA and protein,also to inhibited synthesis of RNA in some degree.
出处
《广东医学院学报》
1995年第1期4-7,共4页
Journal of Guangdong Medical College
