摘要
本实验采用大鼠４０％Ⅲ°烫伤模型，初步观察了选择性肠道清洁法（ＳＤＤ）对肠源性内毒素血症的防治效果。结果发现，防治组动物门、体循环内毒素水平伤后均显著降低（Ｐ＜０．０５～０．０１），各段肠腔内游离内毒素含量较烫伤对照组下降９９．５％以上。且肠道细菌易位率致伤１～５天都明显减少，回肠粘膜二胺氧化酶活性逐渐恢复。防治组大鼠严重烫伤５天存活率提高２６．７％（Ｐ＜０．０５）。本结果提示，该方法对于重症烫伤大鼠肠源性内毒素血症具有显著防护效应，并能抑制肠道细菌的移居与减轻肠粘膜的进一步损害。因此，及早进行ＳＤＤ可能有助于烧伤后肠源性感染及其它并发症的防治。
For the purpose of exploring the effect of selective decontamination of the digestive tract(SDD)on enterogenic endotoxemia,108 rats were subjected to 40% full-thickness scald injury.The results showed that pretreatment with SDD could significantlyattenuate the increase of endotoxin concentration in both portal and systemic blood (P<0.05～0.01),resulting in a reduction of the endotoxin levels of faecal supernatants toless than 0.5%of the untreated control.The incidence of bacterial translocation to themesenteric lymph nodes(MLN)and viscerae was markedly lowered on postburn day 1,3 and5,intestinal diamine oxidase (DAO) activity returned to normal in treatment group 5days later(P>0.05 ).The five-day survival rate in the SDD-treated group increased26.7%as compared with control group(P<0.05).These data suggested that SDD wasvery effective in preventing gut origin endotoxemia and bacterial translocation followingsevere injury.It therefore was possible that SDD might be of value in preventing enterogenicinfection and complications in patients with large burns.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第4期439-443,共5页
Chinese Journal of Pathophysiology
关键词
烫伤
大鼠
内毒素
感染
Burns
Rats
Endotoxins
Infection
