摘要
对６例活检的女阴尖锐湿疣标本进行了光镜、电镜及免疫组化研究。超微结构观察显示，棘细胞层细胞核周线粒体高度肿胀，嵴消失，胞浆明显空泡化，并在２例“挖空细胞”核内发现病毒颗粒不规则聚集成团。免疫组化染色表明，人乳头瘤病毒（ＨＰＶ）阳性细胞多位于颗粒层和棘细胞层，阳性反应几乎都出现在挖空细胞核内。提示尖锐湿疣与ＨＰＶ感染密切相关，“挖空细胞”的形成是ＨＰＶ感染后细胞核与胞浆变性所致，其实质是一种亚细胞结构变性的细胞。
This paper reports the results of a study of 6 cases of condylpma acuminata using the electron microscopic and immunohistochemical techniques.The results showed that the mitochodria around the nuclei were swelling badly with the crests disappearing and the cytoplasm vacuolizating.Irregularly arranged intraneuclear viral granules were foundin 2 of the 6 cases,Human papilloma virus(HPV) antigens were mostly located in the nuclei of the spinosum stratum.This suggests that condyloma acuminata are closely related to HPV infection,The formation of 'halo cells'results from the changes in both the neucleus and the cytoplasm after HPV infection. The'halo cells'are essentially cells in which the structures of the organella are degenerated.
出处
《青岛医学院学报》
1994年第2期121-123,共3页
Acta Academiae Medicinae Qingdao Universitatis
